![AffiAB® Anti-Plexin A1 Antibody [JU50-37]](/web/image/product.product/77639/image_1024/%5BAFG-HB-3177%5D%20AffiAB%C2%AE%20Anti-Plexin%20A1%20Antibody%20%5BJU50-37%5D%20?unique=a48b62f)
AffiAB® Anti-Plexin A1 Antibody [JU50-37]
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q9UIW2 Human; SwissProt: P70206 Mouse; SwissProt: D3Z981 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JU50-37
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, FC
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human Plexin A1 aa 100-200 / 1, 896.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
IF-Cell: 1:50-1:200; FC: 1:50-1:100; WB: 1:500
Molecular Weight
211 kDa
Subcellular location
Cell Membrane.
Positive control
Rat brain tissue lysates, LOVO.