AffiAB® Anti-PLCB3 Antibody
1-Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene. The gene codes for the enzyme phospholipase C β3. The enzyme catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits. PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q01970 Human; SwissProt: Q9NQ66 Human; SwissProt: P51432 Mouse; SwissProt: Q9Z1B3 Mouse; SwissProt: P10687 Rat; SwissProt: Q99JE6 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human aa 2-251.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
PBS (pH7.4) , 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2.06 mg/ml
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:1, 000
; IHC-P: 1:600
Molecular Weight
Predicted band size: 139 kDa
Subcellular location
Nucleus, Cytoplasm.
Positive control
MCF-7 cell lysate, RAW264.7 cell lysate, SH-SY5Y cell lysate, N2A cell lysate, mouse cerebellum tissue lysate, rat cerebellum tissue, human small intestine tissue.