AffiAB® Anti-PLCB2 Antibody
1-Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene. The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q00722 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human PLCB2 aa 950-1185.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
PBS (pH7.4) , 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1.99 mg/ml
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:2, 000; IF-Cell: 1:200
Molecular Weight
Predicted band size: 134 kDa
Subcellular location
Cytosol.
Positive control
HL-60 cell lysate, THP-1 cell lysate, SiHa.