![AffiAB® Anti-PARP2 Antibody [JG34-56]](/web/image/product.product/77376/image_1024/%5BAFG-HB-2898%5D%20AffiAB%C2%AE%20Anti-PARP2%20Antibody%20%5BJG34-56%5D%20?unique=a48b62f)
AffiAB® Anti-PARP2 Antibody [JG34-56]
Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q9UGN5 Human; SwissProt: O88554 Mouse; SwissProt: G3V749 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JG34-56
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, FC
Predicted species reactivity
Mouse, Rat
Immunogen
Recombinant protein within Human PARP2 aa 484-583 / 583.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Apotosis
Recommended dilutions
WB: 1:500-1:1, 000
; FC: 1:50-1:100
Molecular Weight
Predicted band size: 66 kDa
Subcellular location
Chromosome, Nucleus.
Positive control
SiHa cell lysate, Raji cell lysate, SH-SY-5Y.