AffiAB® Anti-Pannexin 2 Antibody
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. Structural component of the gap junctions and the hemichannels. Pannexin 2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic β-cells.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q96RD6 Human; SwissProt: Q6IMP4 Mouse; SwissProt: P60571 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, IF-Cell
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human Pannexin 2 71-95.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB:1:500-1:2, 000; IF-Cell:1:50-1:200; IHC-P:1:100-1:400
Molecular Weight
Predicted band size: 74 kDa
Subcellular location
Cell membrane. Gap junction.
Positive control
HepG2 cell lysates, rat brain tissue, human liver tissue, human kidney tissue, human liver cancer tissue.