AffiAB® Anti-Optineurin Antibody
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q96CV9 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human optineurin aa 1-40.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Autophagy Immunology & Inflammation, Amyotrophic lateral sclerosis
Recommended dilutions
WB:1:500-1:1, 000
; FC:1:50-1:100
Molecular Weight
66 kDa
Subcellular location
Golgi apparatus, trans-Golgi network, Recycling endosome, perinuclear region, autophagosome, Cytoplasmic vesicle.
Positive control
A431 cell lysates, human liver tissue, human kidney tissue, human placenta tissue, MCF-7.