![AffiAB® Anti-OGG1 Antibody [JA18-13]](/web/image/product.product/77279/image_1024/%5BAFG-HB-2789%5D%20AffiAB%C2%AE%20Anti-OGG1%20Antibody%20%5BJA18-13%5D%20?unique=a48b62f)
AffiAB® Anti-OGG1 Antibody [JA18-13]
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7, 8-dihydro-8-oxoguanine and 2, 6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. The OGG1 gene encodes 8 isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: O15527 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA18-13
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human OGG1 aa 296-345 / 345.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Cancer
Recommended dilutions
WB: 1:500
; IHC-P: 1:50-1:200
Molecular Weight
39 kDa
Subcellular location
Mitochondrion. Nucleus
Positive control
Human kidney tissue, Daudi cell lysates.