![AffiAB® Anti-NMDAR1 Antibody [JM11-26]](/web/image/product.product/77208/image_1024/%5BAFG-HB-2714%5D%20AffiAB%C2%AE%20Anti-NMDAR1%20Antibody%20%5BJM11-26%5D%20?unique=a48b62f)
AffiAB® Anti-NMDAR1 Antibody [JM11-26]
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+.Sensitivity to glutamate and channel kinetics depend on the subunit composition.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q05586 Human; SwissProt: P35438 Mouse; SwissProt: P35439 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM11-26
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human NMDAR1 aa 870-910.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Huntington's disease, Neuroscience, Calcium signaling pathway, Alzheimer disease, cAMP signaling pathway, Amyotrophic lateral sclerosis
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:100-1:500; IF-Tissue: 1:100-1:500; IHC-P: 1:50-1:800; FC: 1:50-1:100
Molecular Weight
Predicted band size: 105 kDa
Subcellular location
Cell membrane, postsynaptic cell membrane, postsynaptic density.
Positive control
A549 cell lysate, MCF-7 cell lysate, N2A, SHG-44, SH-SY5Y, mouse brain tissue, rat brain tissue, SH-SY5Y.