AffiAB® Anti-NDRG2 Antibody
The N-myc downstream regulated gene (NDRG) family is comprised of four members, namely NDRG1, NDRG2, NDRG3 and NDRG4, all of which share 57-65% homology. NDRG2 (NDRG family member 2) , also known as SYLD, is a 371 amino acid protein that localizes to both the cytoplasm and the perinuclear region in neurons. Expressed at high levels in heart, brain, dendritic cells, salivary gland and skeletal muscle and at lower levels in liver and kidney, NDRG2 is thought to be involved in dendritic and neuronal cell differentiation and outgrowth. Additionally, NDRG2 expression is downregulated in a variety of carcinomas, including liver cancer, pancreatic cancer and meningioma, suggesting a possible role for NDRG2 in tumor suppression. NDRG2 is found in brain lesions of Alzheimer Disease (AD) -affected patients and is thought to be associated with the progression of AD. Five isoforms of NDRG2 exist due to alternative splicing events.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q9UN36 Human; SwissProt: Q9QYG0 Mouse; SwissProt: Q8VBU2 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human NDRG2 aa 13-160 / 371.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Neuroscience
Recommended dilutions
WB: 1:500-1:1, 000; IF-Cell: 1:50-1:200; IHC-P: 1:50-1:100; FC: 1:50-1:100
Molecular Weight
41 kDa
Subcellular location
Cytoplasm.
Positive control
Mouse brain tissue, mouse skeletal muscle tissue, HepG2, LOVO, SH-SY-5Y, rat brain tissue, human liver tissue, human prostate tissue.