AffiAB® Anti-NCAM-L1 Antibody
The neural cell adhesion molecule L1 (NCAM-L1) is an immunoglobulin superfamily adhesion molecule that is critical for neural development, involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Defects in L1CAM are the cause of hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS) . Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. Defects in L1CAM are also the cause of mental retardation, aphasia, shuffling gait, and adducted thumbs syndrome (MASA) , a X-linked disorder.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P32004 Human; SwissProt: P11627 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human NCAM-L1 aa 1, 208-1, 257 / 1, 257.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Immunology & Inflammation, Neuroscience
Recommended dilutions
WB: 1:500-1:1, 000; IF-Cell: 1:50-1:200; IHC-P: 1:50-1:600; FC: 1:50-1:100
Molecular Weight
Predicted band size: 140 kDa
Subcellular location
Cell membrane, Cell projection, Membrane.
Positive control
Human fetal brain tissue lysate, human brain tissue lysate, Rat brain tissue lysate, Mouse brain tissue lysate, 293T, Hela, A375, human breast cancer tissue, human kidney tissue, mouse kidney tissue, SHG-44.