![AffiAB® Anti-NaV1.7 Antibody [1D6]](/web/image/product.product/77122/image_1024/%5BAFG-HB-2622%5D%20AffiAB%C2%AE%20Anti-NaV1.7%20Antibody%20%5B1D6%5D%20?unique=8544d55)
AffiAB® Anti-NaV1.7 Antibody [1D6]
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na (+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na (+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: Q15858 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgG2b
Clone
1D6
KO/KD
N/A
Species reactivity
Human
Tested applications
IHC-P, IF-Cell, FC, WB
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human NaV17 aa 1, 577-1, 626 / 1, 988.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
IF-Cell: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:200; WB: 1:500
Molecular Weight
Predicted band size: 226 kDa
Subcellular location
Cell membrane, Cell projection.
Positive control
A549, Hela, human colon cancer tissue, human kidney tissue.