AffiAB® Anti-NaV1.7 Antibody
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na+ channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q15858 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human
Tested applications
IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human NaV17 aa 1-50 / 1, 988.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
IHC-P: 1:50-1:1, 000; IF-Cell: 1:50-1:500; FC: 1:50-1:100
Molecular Weight
Predicted band size: 226 kDa
Subcellular location
Cell membrane. Cell projection.
Positive control
A549, Hela, HepG2, SH-SY5Y, human liver cancer tissue, mouse colon tissue.