![AffiAB® Anti-N-Cadherin Antibody [A10-4]](/web/image/product.product/77125/image_1024/%5BAFG-HB-2606%5D%20AffiAB%C2%AE%20Anti-N-Cadherin%20Antibody%20%5BA10-4%5D%20?unique=315d7a9)
AffiAB® Anti-N-Cadherin Antibody [A10-4]
The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: P19022 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgM
Clone
A10-4
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human N-Cadherin aa 401-600 / 906.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Cancer, Immunology & Inflammation
Recommended dilutions
WB: 1:1, 000-1:2, 000; IF-Cell: 1:500; IHC-P: 1:100
Molecular Weight
Predicted band size: 100 kDa
Subcellular location
Cell membrane.
Positive control
Mouse heart tissue lysate, human heart tissue lysate.