AffiAB® Anti-MYO1B Antibody [JE65-01]

Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Tro-ponin facilitates interaction between Actin and Myosin by binding to Ca2+. Troponin is made up of at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interacts with Actin to generate the force for diverse cellular movements, including cyto-kinesis, phagocytosis and muscle contraction. Myosin Ib (MYO1B) , also designated Myosin I α or MYH-1c, is a motor protein that is involved in cell migration, neurite outgrowth and vesicular transport. In multivesicular endosomes, Myosin Ib has been implicated in protein cargo traffic control.