AffiAB® Anti-Myelin PLP Antibody

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CAT# AFG-HB-2582
Size: 100 μL

433.50 433.5 USD 433.50

433.50

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AffiAB® Anti-Myelin PLP Antibody

Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP) . Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease. It is a 4 transmembrane domain protein which is proposed to bind other copies of itself on the extracellular side of the membrane. In a myelin sheath, as the layers of myelin wraps come together, PLP will bind itself and tightly hold the cellular membranes together. This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system (CNS) . The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus–Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. In melanocytic cells PLP1 gene expression may be regulated by MITF.

Antibody type

Rabbit polyclonal Antibody

Uniprot ID

SwissProt: P60201 Human; SwissProt: P60202 Mouse; SwissProt: P60203 Rat

Recombinant

NO

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

N/A

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

WB, IF-Cell, IHC-P

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within huamn PLP1 aa 37-63 (Extracellular domain) .

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Immunogen affinity purified.

Signal pathway

Neuroscience

Recommended dilutions

WB: 1:500-1:2, 000; IF-Cell: 1:50-1:100; IHC-P: 1:50-1:200

Molecular Weight

Predicted Molecular Wt. 30 kDa

Subcellular location

Cell membrane, Myelin membrane.

Positive control

HepG2 cell lysate, mouse cerebellum tissue lysate, mouse brain tissue lysate, rat brain tissue lysate, F9 cell, rat brain tissue, mouse brain tissue.