![AffiAB® Anti-MUC2 Antibody [JA10-92]](/web/image/product.product/77064/image_1024/%5BAFG-HB-2561%5D%20AffiAB%C2%AE%20Anti-MUC2%20Antibody%20%5BJA10-92%5D%20?unique=d31c23b)
AffiAB® Anti-MUC2 Antibody [JA10-92]
The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1) , 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3) . The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major com-ponent of various mucus gels and is broadly expressed in normal and tumor cells.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q02817 Human; SwissProt: Q62635 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA10-92
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human MUC2 aa 5000-5049 / 5179.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Cancer
Recommended dilutions
WB: 1:500-1:1, 000; IF-Cell: 1:100-1:500; IF-Tissue: 1:100-1:500; IHC-P: 1:50-1:200; FC: 1:50-1:100
Molecular Weight
540 kDa
Subcellular location
Secreted.
Positive control
SHSY-5Y cell lysate, SKBR3 cell lysate, Hela, HepG2, SW480, human colon tissue, human small intestine tissue, human colon tissue.