![AffiAB® Anti-MUC1 Antibody [SN06-80]](/web/image/product.product/77060/image_1024/%5BAFG-HB-2557%5D%20AffiAB%C2%AE%20Anti-MUC1%20Antibody%20%5BSN06-80%5D%20?unique=d31c23b)
AffiAB® Anti-MUC1 Antibody [SN06-80]
Mucin 1, cell surface associated (MUC1) , also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen or EMA, is a mucin encoded by the MUC1 gene in humans. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P15941 Human; SwissProt: Q02496 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
SN06-80
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC, IP
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human MUC1 aa 1, 206-1, 255 / 1, 255.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Cancer, Immunology & Inflammation
Recommended dilutions
WB: 1:1, 000-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:1, 000; FC: 1:50-1:100; IP: Use at an assay dependent concentration.
Molecular Weight
Predicted band size: 23 kDa
Subcellular location
Apical cell membrane, Secreted, Cell membrane, Cytoplasm, Nucleus.
Positive control
Hela cell lysate, MCF-7 cell lysate, Hela, B16F1, human lung carcinoma, human endometrial carcinoma, human kidney tissue, MCF-7.