AffiAB® Anti-mSin3A Antibody
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity) . Required for cortical neuron differentiation and callosal axon elongation (By similarity) .
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q96ST3 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human
Tested applications
WB
Predicted species reactivity
Mouse, Rat
Immunogen
Synthetic peptide within human mSin3A aa 1-50.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/ml.
Purity
Immunogen affinity purified.
Signal pathway
Huntington's disease
Recommended dilutions
WB: 1:500-1:1, 000
Molecular Weight
145 kDa
Subcellular location
Nucleus.
Positive control
HL-60 cell lysate, A549 cell lysate, Siha cell lysate.