![AffiAB® Anti-MRP2 Antibody [JA32-01]](/web/image/product.product/77024/image_1024/%5BAFG-HB-2516%5D%20AffiAB%C2%AE%20Anti-MRP2%20Antibody%20%5BJA32-01%5D%20?unique=d31c23b)
AffiAB® Anti-MRP2 Antibody [JA32-01]
Multi-drug resistance protein 2 (MRP2) , also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q92887 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA32-01
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human MRP2 aa 1496-1545 / 1545.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Cancer
Recommended dilutions
WB: 1:500; IF-Cell: 1:50-1:200; IHC-P: 1:50-1:800; FC: 1:50-1:100
Molecular Weight
174 kDa
Subcellular location
Apical cell membrane.
Positive control
HepG2, 293T, human liver tissue, human kidney tissue, human pancreas tissue, A549.