AffiAB® Anti-MMP9 Antibody [10A1]

Matrix metallopeptidase 9 (MMP-9) , also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB) , is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement membrane.MMP9 plays several important functions within neutrophil action, such as degrading extracellular matrix, activation of IL-1β, and cleavage of several chemokines. In a mouse model, MMP9 deficiency resulted in resistance to endotoxin shock, suggesting that MMP9 is important in sepsis.