AffiAB® Anti-Mitoferrin1 Antibody
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009) . Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe (2+) , is then probably delivered to ferrochelatase to catalyze Fe (2+) incorporation into protoprophyrin IX to make heme (By similarity) .
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q9NYZ2 Human; SwissProt: Q920G8 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human Mitoferrin1 aa 289-338.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
PBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500; IF-Cell: 1:50; IHC-P: 1:400
Molecular Weight
Predicted band size: 37 kDa
Subcellular location
Mitochondrion inner membrane.
Positive control
Mouse spleen tissue lysates, mouse brain tissue lysate, THP-1 cell lysate, Hela, mouse brain tissue.