![AffiAB® Anti-MINA53 Antibody [JA11-63]](/web/image/product.product/76988/image_1024/%5BAFG-HB-2479%5D%20AffiAB%C2%AE%20Anti-MINA53%20Antibody%20%5BJA11-63%5D%20?unique=a48b62f)
AffiAB® Anti-MINA53 Antibody [JA11-63]
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3) , leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q8IUF8 Human; SwissProt: Q8CD15 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA11-63
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IF-Cell, IF-Tissue
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human MINA53 aa 416-465 / 465.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200
Molecular Weight
53 kDa
Subcellular location
Nucleus.
Positive control
PC-12 cells lysates