AffiAB® Anti-Meckelin Antibody
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity) . Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC) .
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q5HYA8 Human; SwissProt: Q8BR76 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse
Tested applications
WB, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human Meckelin aa 20-80.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:1, 000; IHC-P: 1:50-1:200; FC: 1:50-1:100
Molecular Weight
112 kDa
Subcellular location
Cytoskeleton, Plasma membrane, Endoplasmic reticulum.
Positive control
MCF-7 cell lysates, mouse kidney tissue, human placenta tissue, human breast cancer tissue, PANC-1.