![AffiAB® Anti-MCM2 Antibody [PD00-90]](/web/image/product.product/76927/image_1024/%5BAFG-HB-2417%5D%20AffiAB%C2%AE%20Anti-MCM2%20Antibody%20%5BPD00-90%5D%20?unique=b83e256)
AffiAB® Anti-MCM2 Antibody [PD00-90]
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P49736 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
PD00-90
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IHC-P, IF-Cell, FC
Predicted species reactivity
N/A
Immunogen
Recombinant protein within
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
PBS (pH7.4) , 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
0.9415 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:2, 000; IHC-P: 1:800-1:2, 000; IF-Cell: 1:50; FC: 1:500-1:1, 000
Molecular Weight
Predicted band size: 102 kDa
Subcellular location
Nucleus, Chromosome.
Positive control
HL-60 cell lysate, SiHa cell lysate, human cervical carcinoma tissue, human tonsil tissue, human ovarian carcinoma tissue, human small intestine tissue, LOVO, HL-60.