![AffiAB® Anti-LY6A Antibody [JM53-11]](/web/image/product.product/76868/image_1024/%5BAFG-HB-2356%5D%20AffiAB%C2%AE%20Anti-LY6A%20Antibody%20%5BJM53-11%5D%20?unique=a48b62f)
AffiAB® Anti-LY6A Antibody [JM53-11]
The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily. The Ly-6 alloantigens represent a family of phosphatidylinositol anchored proteins that play a role in the process of T lymphocyte activation. Ly-6 expression is commonly induced on T and B lymphocytes after activation by mitogens. Ly-6A/E is a phosphatidylinositol-linked transmembrane member of the Ly-6 family that is produced in humans after 4 weeks of age. γ-interferon and TNF regulate Ly-6A/E at the level of transcription and mRNA stabilization in certain thymocytes and T-cells.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P05533 Mouse
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM53-11
KO/KD
N/A
Species reactivity
Mouse
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Mouse LY6A aa 41-90 / 134.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:1, 000-1:5, 000
; IHC-P: 1:50-1:200
Molecular Weight
Predicted band size: 14 kDa
Subcellular location
Cell membrane.
Positive control
Mouse brain tissue, mouse kidney tissue.