![AffiAB® Anti-LXR alpha Antibody [JA20-38]](/web/image/product.product/76867/image_1024/%5BAFG-HB-2354%5D%20AffiAB%C2%AE%20Anti-LXR%20alpha%20Antibody%20%5BJA20-38%5D%20?unique=a48b62f)
AffiAB® Anti-LXR alpha Antibody [JA20-38]
Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q13133 Human; SwissProt: Q9Z0Y9 Mouse; SwissProt: Q62685 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JA20-38
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human LXR alpha aa 49-98 / 447.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
PPAR signaling pathway
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:100; IHC-P: 1:50-1:200; FC: 1:50-1:100
Molecular Weight
Predicted band size: 50 kDa
Subcellular location
Nucleus, Cytoplasm.
Positive control
Human liver tissue lysates, mouse colon tissue lysates, HepG2, human placenta tissue, mouse testis tissue, human spleen tissue, rat brain tissue lysates.