AffiAB® Anti-LRRTM1 Antibody

LRRTM1 Antibody (A-2) is a high quality monoclonal LRRTM1 antibody (also designated LRRTM1 antibody) suitable for the detection of the LRRTM1 protein of mouse, rat and human origin. LRRTM1 Antibody (A-2) is available as both the non-conjugated anti-LRRTM1 antibody form, as well as multiple conjugated forms of anti-LRRTM1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The leucine-rich repeat (LRR) is a 20-30 amino acid motif that forms a hydrophobic α/β horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRRs contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. LRRTM1 (leucine rich repeat transmembrane neuronal 1) is a 522 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and contains ten LRRs. Expressed predominately in forebrain tissue, LRRTM1 is thought to be involved in the development of forebrain structures, specifically by influencing axon trafficking, as well as neuronal differentiation and connectivity. Human LRRTM1 shares 96% amino acid identity with its mouse counterpart, suggesting a conserved role between species. Defects in the gene encoding LRRTM1 may be associated with the pathogenesis of several common neurodevelopmental disorders.