AffiAB® Anti-LMNB2 Antibody
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD) , which is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q03252 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide corresponding to of Human LMNB2 aa 571-620 / 620.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
Apotosis
Recommended dilutions
WB: 1:1, 000-1:2, 000; IF-Cell: 1:200; IHC-P: 1:200
Molecular Weight
Predicted band size: 70 kDa
Subcellular location
Nucleus inner membrane
Positive control
Hela cell lysate, Jurkat cell lysate, HepG2 cell lysate, Raji cell lysate, Hela, HepG2, mouse embryonic stem, human colon carcinoma tissue.