![AffiAB® Anti-L1CAM Antibody [JM11-05]](/web/image/product.product/76792/image_1024/%5BAFG-HB-2274%5D%20AffiAB%C2%AE%20Anti-L1CAM%20Antibody%20%5BJM11-05%5D%20?unique=a48b62f)
AffiAB® Anti-L1CAM Antibody [JM11-05]
Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play an important role in embryogenesis and development. Neuronal cell adhesion molecule (NCAM) expression is observed in a variety of human tumors, including neuroblastomas, rhabdomyosarcomas, Wilm's tumors, Ewing's sarcomas and some primitive myeloid malignancies. The NCAM-L1 adhesion molecule (CD171) plays an important role in axon guidance and cell migration in the nervous system. The presence of NCAM-L1 might contribute to tumor progression by promoting cell adhesion and migration and is known to be expressed by neurons, neuroblastomas and other malignant tumors.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P32004 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM11-05
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human L1CAM aa 900-1135 / 1257.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Immunology & Inflammation, Neuroscience
Recommended dilutions
WB: 1:1, 000-1:5, 000
; IHC-P: 1:50-1:200
Molecular Weight
Predicted band size: 140 kDa
Subcellular location
Cell membrane.
Positive control
Hela cell lysate, human brain tissue lysate, human kidney tissue.