AffiAB® Anti-Kv1.1 potassium channel Antibody [SN66-06]

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CAT# AFG-HB-2270
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-Kv1.1 potassium channel Antibody [SN66-06]

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming -subunits (KVα) , which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KVβ subunits that modify the gating properties of the coexpressed KVα subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: Q09470 Human; SwissProt: P16388 Mouse; SwissProt: P10499 Rat

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

SN66-06

KO/KD

N/A

Species reactivity

Human, Rat

Tested applications

WB, IHC-P, IP

Predicted species reactivity

Mouse

Immunogen

Synthetic peptide within Human KCNA1 aa 491-440 / 495.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:2, 000-1:5, 000 ; IHC-P: 1:50-1:200 ; IP: Use at an assay dependent concentration.

Molecular Weight

Predicted band size: 56 kDa

Subcellular location

Cell membrane, Membrane, Cytoplasmic vesicle, Perikaryon, Endoplasmic reticulum.

Positive control

Human brain tissue lysates, rat brain tissue.