AffiAB® Anti-Kidins220 Antibody [3-B6]

Kinase D-interacting substrate 220 (Kidins220) , also known as ARMS (ankyrin-rich membrane spanning) is an integral plasma membrane protein predominantly expressed in brain and neurons that presents a polarized location in neural cells, concentrating at the tip of extending neurites and in plasma membrane micro-domains corresponding to lipid rafts. The primary amino acid sequence of Kidins220 reveals 11 ankyrin repeats, 4 trans-membrane domains, a proline-rich region, a sterile-α motif (or SAM) domain, and a type I postsynaptic density-95/discs large/zonula occludens-1 (PDZ) -binding motif at the very C-terminus.