![AffiAB® Anti-KHSRP Antibody [JE41-64]](/web/image/product.product/76748/image_1024/%5BAFG-HB-2228%5D%20AffiAB%C2%AE%20Anti-KHSRP%20Antibody%20%5BJE41-64%5D%20?unique=d31c23b)
AffiAB® Anti-KHSRP Antibody [JE41-64]
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity) . Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE) . May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q92945 Human; SwissProt: Q3U0V1 Mouse; SwissProt: Q99PF5 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JE41-64
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, IP
Predicted species reactivity
N/A
Immunogen
Recombinant protein within Human KHSRP aa 1-220 / 712.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200; IP: 1:10-1:50
Molecular Weight
73 kDa
Subcellular location
Nucleus. Cytoplasm.
Positive control
293 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, 293T, LOVO, SH-SY5Y, rat testis tissue, human lung carcinoma tissue, human colon tissue, human kidney tissue, mouse brain tissue.