![AffiAB® Anti-KHSRP Antibody [A7-B0]](/web/image/product.product/76747/image_1024/%5BAFG-HB-2227%5D%20AffiAB%C2%AE%20Anti-KHSRP%20Antibody%20%5BA7-B0%5D%20?unique=d31c23b)
AffiAB® Anti-KHSRP Antibody [A7-B0]
Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE) . May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: Q92945 Human; SwissProt: Q3U0V1 Mouse; SwissProt: Q99PF5 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgM
Clone
A7-B0
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human KHSRP aa 625-674 / 711.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein L affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000
; FC: 1:50-1:100
Molecular Weight
Predicted band size: 73 kDa
Subcellular location
Nucleus.
Positive control
Jurkat cell lysate, HT-29.