AffiAB® Anti-KDM5B Antibody
PLU-1 is a large (1, 544 amino acid) nuclear protein that interacts with brain factor-1 (BF-1) and paired box 9 (PAX9) , both of which are developmental transcription factors. PLU-1 belongs to the testis-cancer antigen group of proteins and is a member of the ARID family of DNA binding proteins. It is a multi-domain protein with strong transcriptional repression properties. PLU-1 shows restricted expression in adult tissues, with high expression in testis and transient expression in the pregnant mammary gland. Both the PLU-1 gene and the PLU-1 protein product are specifically upregulated in breast cancer. PLU-1 may be important in meiotic transcription because of its apparent association with chromatin.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q9UGL1 Human; SwissProt: Q80Y84 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
IF-Cell, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human KDM5B aa 960-1, 009 / 1, 544.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
IF-Cell: 1:100-1:500; IHC-P: 1:50-1:200
Molecular Weight
Predicted band size: 176 kDa
Subcellular location
Nucleus.
Positive control
MCF-7, PC-3M, SH-SY5Y, rat epididymis tissue, mouse testis tissue.