![AffiAB® Anti-IRF5 Antibody [SD203-07]](/web/image/product.product/74926/image_1024/%5BAFG-HB-2158%5D%20AffiAB%C2%AE%20Anti-IRF5%20Antibody%20%5BSD203-07%5D%20?unique=a48b62f)
AffiAB® Anti-IRF5 Antibody [SD203-07]
Interferon regulatory factor 5 (IRF-5) , belongs to the IRF family of DNA-binding factors, which includes IRF-1, IRF-2, IRF-3, IRF-4, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP) . The IRF family regulate both interferon and interferon-inducible genes. IRF-5, like IRF-3 and IRF-7, is a direct transducer of virus-mediated signaling and plays a role in the expression of multiple cytokines/chemokines. Although IRF-5 is a direct target of p53, its cell cycle regulatory and proapoptotic effects are p53 independent.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q13568 Human; SwissProt: P56477 Mouse; Unigene:203787 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
SD203-07
KO/KD
N/A
Species reactivity
Human, Rat
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Predicted species reactivity
Mouse
Immunogen
Recombinant protein within human IRF5 aa 1-200.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Immunology & Inflammation
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:100; IP: Use at an assay dependent concentration.
Molecular Weight
56 kDa
Subcellular location
Nucleus, Cytoplasm.
Positive control
THP-1 cell lysates, HepG2, RH-35, human spleen tissue, Hela.