![AffiAB® Anti-IREB2 Antibody [9D1]](/web/image/product.product/74922/image_1024/%5BAFG-HB-2153%5D%20AffiAB%C2%AE%20Anti-IREB2%20Antibody%20%5B9D1%5D%20?unique=b83e256)
AffiAB® Anti-IREB2 Antibody [9D1]
RNA-binding protein that binds to iron-responsive elements (IRES) , which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Antibody type
Mouse monoclonal Antibody
Uniprot ID
SwissProt: P48200 Human
Recombinant
NO
Conjugation
Non-conjugated
Host
Mouse
Isotype
IgG1
Clone
9D1
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human IREB2 aa 1-963.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 mg/mL.
Purity
Protein G affinity purified.
Signal pathway
Cardiovascular
Recommended dilutions
WB: 1:500-1:2, 000; IHC-P: 1:100-1:500
Molecular Weight
Predicted band size: 105/38 kDa
Subcellular location
Cytoplasm.
Positive control
Jurkat cell lysate, Daudi cell lysate, human liver tissue lysate, human placenta tissue.