![AffiAB® Anti-HDAC1 Antibody [SY12-04]](/web/image/product.product/74579/image_1024/%5BAFG-HB-1789%5D%20AffiAB%C2%AE%20Anti-HDAC1%20Antibody%20%5BSY12-04%5D%20?unique=a48b62f)
AffiAB® Anti-HDAC1 Antibody [SY12-04]
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q13547 Human; SwissProt: O09106 Mouse; SwissProt: Q4QQW4 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
SY12-04
KO/KD
Knockout validated
Species reactivity
Human, Mouse
Tested applications
WB, IHC-P, IF-Cell
Predicted species reactivity
Rat
Immunogen
Synthetic peptide within human HDAC1 aa 420-460.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Immunology & Inflammation, Huntington's disease, Cardiovascular, Notch signaling pathway
Recommended dilutions
WB: 1:500-1:2, 000; IHC-P: 1:50-1:800; IF-Cell: 1:50
Molecular Weight
Predicted band size: 55 kDa
Subcellular location
Nucleus.
Positive control
HepG2 cell lysate, MCF-7 cell lysate, Jurkat cell lysate, human colon tissue, mouse colon tissue, mouse pancreas tissue, human pancreas tissue, SiHa, mouse lymph nodes tissue.