AffiAB® Anti-GTF2F2 Antibody [JE56-15]

TFIIF RAP 30 Antibody is a high quality monoclonal TFIIF RAP 30 antibody (also designated TFIIF RAP 30 antibody) suitable for the detection of the TFIIF RAP 30 protein of mouse, rat and human origin. TFIIF RAP 30 Antibody is available as both the non-conjugated anti-TFIIF RAP 30 antibody form, as well as multiple conjugated forms of anti-TFIIF RAP 30 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH; and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promotor elements such as the TATA box generally located 25-30 base pairs upstream of the transcription start site. TFIIF, a heteromer composed of a small (RAP 30) and a large (RAP 74) subunit, is required for RNA polymerase II to assemble into a preinitiation complex formed by promotor DNA and the general factors TFIID, IIA and IIB. In addition, TFIIF stimulates transcription elongation by RNA polymerase II.