![AffiAB® Anti-GSK3 beta Antibody [SY28-03]](/web/image/product.product/74556/image_1024/%5BAFG-HB-1765%5D%20AffiAB%C2%AE%20Anti-GSK3%20beta%20Antibody%20%5BSY28-03%5D%20?unique=d31c23b)
AffiAB® Anti-GSK3 beta Antibody [SY28-03]
Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene. Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar disorder. Glycogen synthase kinase-3 (GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and an inactivating agent of glycogen synthase. Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. It might be a new therapeutic target for ischemic stroke.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P49841 Human; SwissProt: Q9WV60 Mouse; SwissProt: P18266 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
SY28-03
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within human GSK3 beta aa 360-400.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Neuroscience, PI3K-AKT, Cardiovascular, ErbB signaling pathway, Immunology & Inflammation, Alzheimer disease
Recommended dilutions
WB: 1:500-1:2, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:100
Molecular Weight
Predicted band size: 47 kDa
Subcellular location
Cytoplasm, Nucleus, Cell membrane.
Positive control
PC-12 cell lysate, Hela cell lysate, Hela, PC-3M, SKOV-3, human breast tissue, human breast carcinoma tissue, mouse testis tissue, mouse prostate tissue, NIH/3T3 cell lysate, 293 cell lysate.