![AffiAB® Anti-Glucagon Antibody [JF33-10]](/web/image/product.product/74453/image_1024/%5BAFG-HB-1656%5D%20AffiAB%C2%AE%20Anti-Glucagon%20Antibody%20%5BJF33-10%5D%20?unique=a48b62f)
AffiAB® Anti-Glucagon Antibody [JF33-10]
Glucagon is a pancreatic hormone that functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1) , Glucagon-like peptide-2 (GLP-2) , VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the Glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P01275 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JF33-10
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human GLP1 aa 65-150.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
cAMP signaling pathway, Cardiovascular
Recommended dilutions
WB: 1; 500-1:1, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200
Molecular Weight
21/8/4 kDa
Subcellular location
Secreted.
Positive control
PC-12, SW480, human pancreas tissue.