AffiAB® Anti-GLP-1R Antibody
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: P43220 Human; SwissProt: O35659 Mouse; SwissProt: P32301 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, IF-Cell
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human GLP-1R aa 24-175.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:500-1:2, 000; IHC-P: 1:100-1:500; IF-Cell: 1:50-1:100
Molecular Weight
predicted 53 kDa
Subcellular location
Cell membrane.
Positive control
Mouse stomach tissue lysates, SH-SY5Y cell lysate, rat stomach tissue lysate, SH-SY5Y, rat pancreas tissue, human pancreas tissue.