AffiAB® Anti-GLO1 Antibody [JU44-11]

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CAT# AFG-HB-1653
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-GLO1 Antibody [JU44-11]

The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP) . Glyoxalase I (GLO1) , a member of the glyoxalase family, is effective in eliminating GDP. Overexpression or silencing of Glyoxalase I in mice brain suggests an association between Glyoxalase I and anxiety. Glyoxalase I has three isoforms generated from two alleles in the genome which forms two homodimers and one heterodimer, each subunit binding one zinc ion. Research demonstrates that GLO1 gene expression is induced in colon carcinoma. Both an insulin response element (IRE) , and a zinc metal response element (MRE) in the promoter region of the GLO1 gene have been identified.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: Q04760 Human; SwissProt: SwissProt: Q9CPU0 Mouse; SwissProt: SwissProt: Q6P7Q4 Rat

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

JU44-11

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

WB, IF-Cell, IHC-P, FC

Predicted species reactivity

N/A

Immunogen

Recombinant protein within Human GLO1 aa 1-120 / 184.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:500-1:2, 000; IF-Cell: 1:100-1:500; IHC-P: 1:100-1:500; FC: 1:50-1:100

Molecular Weight

21 kDa

Subcellular location

Cytoplasm. Nucleus.

Positive control

Mouse testis tissue lysate, C2C12 cell lysate, 293 cell lysate, rat spleen tissue lysate, 293T, HUVEC, SH-SY5Y, rat epididymis tissue, human thyroid tissue, Hela.