AffiAB® Anti-GBP1 Antibody [JE60-78]

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CAT# AFG-HB-1614
Size: 100 μL

496.50 496.5 USD 496.50

496.50

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AffiAB® Anti-GBP1 Antibody [JE60-78]

GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by INF-γ during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi′s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P32455 Human

Recombinant

YES

Conjugation

Non-conjugated

Host

Rabbit

Isotype

IgG

Clone

JE60-78

KO/KD

N/A

Species reactivity

Human

Tested applications

WB, IHC-P

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within human GBP1 aa 543-592/592.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

WB: 1:500-1:2, 000 ; IHC-P: 1:50

Molecular Weight

68 kDa

Subcellular location

Cell membrane, Secreted, Golgi apparatus membrane, Cytoplasm.

Positive control

Human small intestine tissue lysates, human small intestine tissue.