![AffiAB® Anti-GBA Antibody [JM10-76]](/web/image/product.product/74413/image_1024/%5BAFG-HB-1612%5D%20AffiAB%C2%AE%20Anti-GBA%20Antibody%20%5BJM10-76%5D%20?unique=a48b62f)
AffiAB® Anti-GBA Antibody [JM10-76]
β-Glucosidase is a predominantly liver enzyme which efficiently hydrolyzes β-D-glucoside and β-D-galactoside. Defects in β-glucosidase cause Gaucher disease, an inherited condition distinguished by the accumulation of glucosylceramide within the cells of the reticuloendothelial system. β-Glucosidase is used in enzyme replacement treatment aimed at treating Gaucher disease. The absorption of dietary flavonoid glycosides in humans involves a critical deglycosylation step that is mediated by epithelial β-glucosidases.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P04062 Human; SwissProt: P17439 Mouse; Entrez Gene:684536 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JM10-76
KO/KD
Knockout validated
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human GBA aa 477-534 / 536.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
Neuroscience
Recommended dilutions
WB: 1:500-1:2, 000
; IHC-P: 1:50-1:200
Molecular Weight
Predicted band size: 60 kDa
Subcellular location
Lysosome membrane.
Positive control
SK-Br-3 cell lysate, A549 cell lysate, MCF-7 cell lysate, Wild-type HEK293T whole cell lysates, human breast carcinoma tissue, human liver tissue, human pancreas tissue, human kidney tissue, rat liver tissue, rat kidney tissue, mouse pancreas tissue.