AffiAB® Anti-Gab2 Antibody
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q9UQC2 Human; SwissProt: Q9Z1S8 Mouse; SwissProt: Q9EQH1 Rat
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, IF-Cell, FC
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human Gab2 aa 450-676 / 676.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB:1:500-1:2, 000; IHC-P:1:100-1:400; IF-Cell: 1:50-1:100; FC: 1:100-1:500
Molecular Weight
74 kDa
Subcellular location
Cell membrane, Cytoplasm.
Positive control
Hela cell lysate, mouse brain tissue lysate, rat brain tissue lysates, SHSY5Y cell lysates, rat kidney tissue, human throid gland tissue, human esophagus tissue, A549, SH-SY5Y.