AffiAB® Anti-FYCO1 Antibody
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2) .
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q9BQS8 Human; SwissProt: Q8VDC1 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human, Mouse, Rat
Tested applications
WB, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Recombinant protein within human FYCO1 aa 1-200.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB:1:500
; IHC-P:1:200-1:1, 000
; FC:1:50-1:100
Molecular Weight
167 kDa
Subcellular location
Lysosome, Endosome, autophagosome.
Positive control
SK-Br-3 cell lysates, rat testis tissue, human liver tissue, human thyroid tissue, human colon tissue, mouse colon tissue, 293.