![AffiAB® Anti-FYB Antibody [JE44-80]](/web/image/product.product/74348/image_1024/%5BAFG-HB-1534%5D%20AffiAB%C2%AE%20Anti-FYB%20Antibody%20%5BJE44-80%5D%20?unique=a48b62f)
AffiAB® Anti-FYB Antibody [JE44-80]
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2) . Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: O15117 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JE44-80
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human FYB aa 701-750 / 783.
Storage
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/ml.
Purity
Protein A affinity purified.
Signal pathway
Immunology & Inflammation
Recommended dilutions
WB: 1:500-1:1, 000
; IHC-P: 1:50-1:200
; FC: 1:50-1:100
Molecular Weight
Predicted band size: 85 kDa
Subcellular location
Cell junction, Cytoplasm, Nucleus.
Positive control
U937 cell lysate, Jurkat cell lysate, human tonsil tissue, human appendix tissue, human spleen tissue, HepG2.