![AffiAB® Anti-Fragilis Antibody [JU73-02]](/web/image/product.product/74336/image_1024/%5BAFG-HB-1521%5D%20AffiAB%C2%AE%20Anti-Fragilis%20Antibody%20%5BJU73-02%5D%20?unique=a48b62f)
AffiAB® Anti-Fragilis Antibody [JU73-02]
Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene. It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked. This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1. The prevalence of this mutation is thought to be approximately 1/400 in European populations.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: Q01628 Human
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JU73-02
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC
Predicted species reactivity
N/A
Immunogen
Synthetic peptide within Human Fragilis aa 1-50 / 133.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:1, 000-1:5, 000; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:200; FC: 1:50-1:100
Molecular Weight
Predicted band size: 15 kDa
Subcellular location
Cell membrane, Late endosome membrane, Lysosome membrane, perinuclear region.
Positive control
Hela cell lysate, HepG2 cell lysate, HUVEC, MCF-7, PC-3M, human breast carcinoma tissue, human colon carcinoma tissue, MCF-7.