![AffiAB® Anti-FOXO4 Antibody [JJ09-11]](/web/image/product.product/74327/image_1024/%5BAFG-HB-1509%5D%20AffiAB%C2%AE%20Anti-FOXO4%20Antibody%20%5BJJ09-11%5D%20?unique=a48b62f)
AffiAB® Anti-FOXO4 Antibody [JJ09-11]
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Antibody type
Recombinant Rabbit monoclonal Antibody
Uniprot ID
SwissProt: P98177 Human; SwissProt: Q9WVH3 Mouse; Unigene:19646 Rat
Recombinant
YES
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
JJ09-11
KO/KD
N/A
Species reactivity
Human
Tested applications
WB, IF-Cell, IF-Tissue, IHC-P, FC, IP
Predicted species reactivity
Mouse, Rat
Immunogen
Recombinant protein within Human FOXO4 aa 456-505 / 505.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*TBS (pH7.4) , 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Protein A affinity purified.
Signal pathway
RAS signaling pathway, Immunology & Inflammation
Recommended dilutions
WB: 1:500; IF-Cell: 1:50-1:200; IF-Tissue: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:100; IP: Use at an assay dependent concentration.
Molecular Weight
Predicted band size: 54 kDa
Subcellular location
Nucleus, Cytoplasm.
Positive control
293T, Hela, HepG2, human placenta tissue, 293.