AffiAB® Anti-FOXD3 Antibody
Forkhead box protein D3 (FOXD3) acts as a transcriptional repressor and binds to the consensus sequence 5'-A [AT] T [AG] TTTGTTT-3'. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord. A variety of growth factors induce FoxD3 expression, including FGF8 and SNAIL, maintaining the effected cells in an undifferentiated state.
Antibody type
Rabbit polyclonal Antibody
Uniprot ID
SwissProt: Q9UJU5 Human; SwissProt: Q61060 Mouse
Recombinant
NO
Conjugation
Non-conjugated
Host
Rabbit
Isotype
IgG
Clone
N/A
KO/KD
N/A
Species reactivity
Human
Tested applications
WB
Predicted species reactivity
N/A
Immunogen
Synthetic peptide corresponding to of Mouse FOXD3 aa 1-50 / 465.
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Form
Liquid
Storage buffer
1*PBS (pH7.4) , 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 mg/mL.
Purity
Immunogen affinity purified.
Signal pathway
N/A
Recommended dilutions
WB: 1:1, 000
Molecular Weight
Predicted band size: 48 kDa
Subcellular location
Nucleus
Positive control
NCCIT